CAS Number

6184-17-4

Molecular Formula

C₁₇H₂₄N₄NaO₁₀P

Molecular Weight

498.36

Molecular Structure

Packing

10kg/drum

Shelf life

24 months

Storage

Keep away from light and seal it. Store in a cool and dry place.

Application

Used as a vitamin B₂ supplement to treat/prevent riboflavin deficiency.

Content

73.0% to 79.0% of riboflavin

(C17H20N406; Mr 376.4) (dried substance)

Appearance

Yellow or orange-yellow, crystalline, hygroscopic powder

Solubility

Soluble in water, very slightly soluble in ethanol (96%)

Identification

Be positive

PH

5.0~6.5

Specific Optical Rotation

+38.0° to+ 43.0°(dried substance)

Impurity E

The filtrate is not more intensely coloured than reference solution BY₆

Related Substances

Impurity D≤6.0%

Impurity F≤0.7%

Impurity G≤0.6%

Impurity H≤0.4%

Unspecified impurities: for each impurity≤0.2%

Total≤8.0%;

Composition

Riboflavin 5#39;-(sodium hydrogen phosphate) hydrate≥65.0%

Riboflavin4#39;-(sodium hydrogen phosphate)

hydrate≤12.0%

Riboflavin 3#39;-(sodium hydrogen phosphate) hydrate≤7.0%

Riboflavin 3#39;5#39;-bis(sodium hydrogen phosphate) hydrate≤3.5%

Riboflavin 4#39;,5 #39;-bis(sodium hydrogen phosphate) hydrate≤3.5%

Riboflavin 3#39;,4#39;-bis(sodium hydrogen phosphate) hydrate≤1.0%

Inorganic Phosphate

≤1.0%

Loss on drying

≤8.0%

Heavy Metal

≤10mg/kg

Residual Solvents

Ethanol≤0.5%

Acetonitrile≤0.041%

Pyridine ≤0.02%

Microorganism Limits

Aerobe bacteria≤800cfu/g

Moulds and yeasts≤80cfu/g

E.coli: ND

Standard

EP 11.2